| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Curcumin | 📋 | ✍ | ⛔ | | 38616356 | Neuroprotective and anti-inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38715063 | Causal association between low vitamin D and polycystic ovary syndrome: a bidirectional mendelian randomization study |
| Metformin | 📋 | ✍ | ⛔ | | 38582410 | The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats |
| Resveratrol | 📋 | ✍ | ⛔ | | 38504306 | Unraveling the therapeutic efficacy of resveratrol in Alzheimer's disease: an umbrella review of systematic evidence |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38654472 | Cannabidiol attenuates seizure susceptibility and behavioural deficits in adult CDKL5R59X knock-in mice |
| Melatonin | 📋 | ✍ | ⛔ | | 38561619 | The Therapeutic Potential of Melatonin in Alzheimer's Disease: A Comprehensive Review |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38593704 | Total ginsenosides decrease Aβ production through activating PPARγ |
| Berberine | 📋 | ✍ | ⛔ | | 38678955 | Berberine alleviates Alzheimer's disease by regulating the gut microenvironment, restoring the gut barrier and brain-gut axis balance |
| EGCG | 📋 | ✍ | ⛔ | | 38275516 | Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease |
| Vitamin E | 📋 | ✍ | ⛔ | | 37569747 | Effect of Vitamin E on Transcriptomic Alterations in Alzheimer's Disease |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38409715 | DHA and EPA in Sickle Cell Disease Favor Clinical Improvement and Contribute to Better Quality of Life: A Qualitative Systematic Review |
| Quercetin | 📋 | ✍ | ⛔ | | 38637876 | Effects of quercetin on polycystic ovary syndrome in animal models: a systematic review and meta-analysis |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38654507 | Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease |
| Genistein | 📋 | ✍ | ⛔ | | 38275516 | Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Vitamin C | 📋 | ✍ | ⛔ | | 37537932 | Therapeutic Potential of Ascorbic Acid in the Management of Alzheimer's Disease: An Update |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38201863 | Astaxanthin Ameliorates Worsened Muscle Dysfunction of MDX Mice Fed with a High-Fat Diet through Reducing Lipotoxicity and Regulating Gut Microbiota |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 38613004 | Impact of 1-Year Supplementation with High-Rich Docosahexaenoic Acid (DHA) on Clinical Variables and Inflammatory Biomarkers in Pediatric Cystic Fibrosis: A Randomized Double-Blind Controlled Trial |
| CoQ10 | 📋 | ✍ | ⛔ | | 38473909 | Ameliorative Effect of Coenzyme Q10 on Phenotypic Transformation in Human Smooth Muscle Cells with FBN1 Knockdown |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 37841396 | The effects of N-acetylcysteine supplement on metabolic parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis |
| Food | 📋 | | | | 38515359 | Effect of Dietary Habits on Alzheimer's Disease Progression |
| Luteolin | 📋 | ✍ | ⛔ | | 38705425 | Luteolin and its analog luteolin-7-methylether from Leonurus japonicus Houtt suppress aromatase-mediated estrogen biosynthesis to alleviate polycystic ovary syndrome by the inhibition of tumor progression locus 2 |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 38599886 | Systematic Review of the roles of Inositol and Vitamin D in improving fertility among patients with Polycystic Ovary Syndrome |
| Ginseng | 📋 | ✍ | ⛔ | | 38707644 | Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia |
| Selenium | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38438062 | Sulforaphane's role in Redefining autophagic Responses in depression associated with polycystic ovarian syndrome: Unveiling the SIRT1/AMPK/LKB1 pathway connection |
| Cinnamon | 📋 | ✍ | ⛔ | | 38671840 | Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders |
| TUDCA | 📋 | ✍ | ⛔ | | 38440398 | Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer's disease |
| Baicalein | 📋 | ✍ | ⛔ | | 38518646 | Baicalein improves the symptoms of polycystic ovary syndrome by mitigating oxidative stress and ferroptosis in the ovary and gravid placenta |
| Medicinal Plants | 📋 | | | | 38419106 | A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer's disease based on the neuroinflammatory |
| Micronutrients | 📋 | | ⛔ | | 38623983 | Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38700503 | Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials |
| L-Arginine | 📋 | ✍ | ⛔ | | 37660966 | Protective effects of L-arginine on Alzheimer's disease: Modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model |
| Phytochemicals | 📋 | | | | 38471283 | Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease |
| Zinc | 📋 | ✍ | ⛔ | | 38239836 | Association of antioxidants use with the risk of dementia among community-dwelling adults in the United Kingdom biobank |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 38369215 | The intestinal microbial metabolite acetyl l-carnitine improves gut inflammation and immune homeostasis via CADM2 |
| Ginkgolides | 📋 | | | | 38676673 | [Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease] |
| Gotu Kola | 📋 | ✍ | ⛔ | | 37440991 | Prediction of Translational Regulation by Network Interaction in Synaptic Plasticity Induced with Centella asiatica |
| Saffron | 📋 | ✍ | ⛔ | | 36045883 | Investigating the Effect of Crocus sativus (Saffron) Petal Hydro-alcoholic Extract on Ovarian Follicle, Inflammatory Markers, and Antioxidant Enzymes in Mice Model of Polycystic Ovary Syndrome |
| Schisandra | 📋 | ✍ | ⛔ | | 38565361 | Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 38700503 | Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials |
| Coconut Oil | 📋 | | ⛔ | | 38052316 | Coconut oil ameliorates behavioral and biochemical alterations induced by D-GAL/AlCl3 in rats |
| Icariin | 📋 | ✍ | | | 38412923 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| Magnesium | 📋 | ✍ | ⛔ | | 37393389 | The Effect of Magnesium Supplementation on Insulin Resistance and Metabolic Profiles in Women with Polycystic Ovary Syndrome: a Randomized Clinical Trial |
| Salidroside | 📋 | | | | 36965372 | Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38487137 | Protective Effect of Ferulic Acid on Acetylcholinesterase and Amyloid Beta Peptide Plaque Formation in Alzheimer's Disease: An In Vitro Study |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 38241160 | Nicotinamide riboside, pterostilbene and ibudilast protect motor neurons and extend survival in ALS mice |
| Puerarin | 📋 | ✍ | ⛔ | | 38412923 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| Astragalosides | 📋 | ✍ | ⛔ | | 38412923 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| Goji Berry | 📋 | ✍ | ⛔ | | 38653878 | Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer's Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38328786 | A randomized placebo-controlled clinical trial of oral green tea epigallocatechin 3-gallate on erythropoiesis and oxidative stress in transfusion-dependent β-thalassemia patients |
| L-Carnitine | 📋 | ✍ | ⛔ | | 37760915 | Acyl-Carnitines Exert Positive Effects on Mitochondrial Activity under Oxidative Stress in Mouse Oocytes: A Potential Mechanism Underlying Carnitine Efficacy on PCOS |
| Nobiletin | 📋 | ✍ | | | 37598127 | The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism |
| Probiotics | 📋 | ✍ | ⛔ | | 38510467 | Slowing Alzheimer's disease progression through probiotic supplementation |
| Rapamycin | 📋 | ✍ | | | 38640155 | Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38489176 | Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease |
| Lycopene | 📋 | ✍ | ⛔ | | 37320982 | Lycopene destabilizes preformed Aβ fibrils: Mechanistic insights from all-atom molecular dynamics simulation |
| Naringenin | 📋 | ✍ | ⛔ | | 38009056 | Naringenin alleviates the excessive lipid deposition of polycystic ovary syndrome rats and insulin-resistant adipocytes by promoting PKGIα |
| Naringin | 📋 | ✍ | ⛔ | | 38557865 | Naringin Alleviates Intestinal Fibrosis by Inhibiting ER Stress-Induced PAR2 Activation |
| Pterostilbene | 📋 | ✍ | ⛔ | | 38241160 | Nicotinamide riboside, pterostilbene and ibudilast protect motor neurons and extend survival in ALS mice |
| Silymarin | 📋 | ✍ | ⛔ | | 38353101 | Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease |
| Andrographolide | 📋 | | | | 37179044 | Andrographolide exerts a neuroprotective effect by regulating the LRP1-mediated PPARγ/NF-κB pathway |
| Antioxidants | 📋 | | ⛔ | | 38251706 | Efficacy of antioxidant supplementation in improving endocrine, hormonal, inflammatory, and metabolic statuses of PCOS: a meta-analysis and systematic review |
| Apigenin | 📋 | ✍ | ⛔ | | 36646447 | A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment |
| Crocin | 📋 | ✍ | ⛔ | | 38227208 | Interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of Alzheimer's disease |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38373507 | N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma |
| Fisetin | 📋 | ✍ | ⛔ | | 37769468 | Inhibition mechanism of fisetin on acetylcholinesterase and its synergistic effect with galantamine |
| Ashwagandha | 📋 | ✍ | ⛔ | | 34276370 | Development of Synergy-Based Combination for Learning and Memory Using in vitro, in vivo and TLC-MS-Bioautographic Studies |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 37248896 | Boswellic Acids Improve Clinical Cognitive Scores and Reduce Systemic Inflammation in Patients with Mild to Moderate Alzheimer's Disease |
| Olive Oil | 📋 | ✍ | ⛔ | | 38339193 | Extra-Virgin Olive Oil in Alzheimer's Disease: A Comprehensive Review of Cellular, Animal, and Clinical Studies |
| Pomegranate | 📋 | | ⛔ | | 38074891 | A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38720773 | Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease |
| Rutin | 📋 | ✍ | ⛔ | | 36902309 | A Diet Containing Rutin Ameliorates Brain Intracellular Redox Homeostasis in a Mouse Model of Alzheimer's Disease |
| Thymoquinone | 📋 | | ⛔ | | 38031940 | Effects of thymoquinone and memantine alone and in combination on memory and hippocampal morphology in rats with streptozotocin-induced Alzheimer's disease |
| Anthocyanins | 📋 | ✍ | ⛔ | | 37346934 | Attenuation of amyloid-β-induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 38078918 | The effect of ellagic acid on sex hormones and miRNA-21 expression in rats with polycystic ovary syndrome |
| Fish Oil | 📋 | ✍ | ⛔ | | 36858183 | Dietary fish oil improves autistic behaviors and gut homeostasis by altering the gut microbial composition in a mouse model of fragile X syndrome |
| Hesperidin | 📋 | ✍ | ⛔ | | 37913913 | Hesperidin ameliorates Amyloid-β toxicity and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans through acr-16 mediated activation of the autophagy pathway |
| Licorice Root | 📋 | ✍ | ⛔ | | 34858128 | Anti-inflammatory Effects of a Novel Herbal Extract in the Muscle and Spinal Cord of an Amyotrophic Lateral Sclerosis Animal Model |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 37970416 | Assessment of hepatoprotective, nephroprotective efficacy, and antioxidative potential of Moringa oleifera leaf powder and ethanolic extract against PCOS-induced female albino mice ( Mus Musculus) |
| NMN | 📋 | ✍ | ⛔ | | 38504592 | NAD+ precursor supplementation modulates neurite complexity and survival in motor neurons from ALS models |
| Piperine | 📋 | ✍ | ⛔ | | 33544523 | Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine |
| Rosmarinic Acid | 📋 | ✍ | | | 36618920 | Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer's disease |
| Caffeine | 📋 | ✍ | ⛔ | | 37371547 | Caffeine for Prevention of Alzheimer's Disease: Is the A2A Adenosine Receptor Its Target? |
| Choline | 📋 | ✍ | ⛔ | | 37214864 | Low circulating choline, a modifiable dietary factor, is associated with the pathological progression and metabolome dysfunction in Alzheimer's disease |
| Coffee | 📋 | ✍ | ⛔ | | 38714417 | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| Flavonoids | 📋 | | ⛔ | | 36499159 | The Neuroprotective Potentiality of Flavonoids on Alzheimer's Disease |
| Gallic Acid | 📋 | | ⛔ | | 38549642 | Gallic Acid Alleviates Cognitive Impairment by Promoting Neurogenesis via the GSK3β-Nrf2 Signaling Pathway in an APP/PS1 Mouse Model |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 37832335 | Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children |
| Oleuropein | 📋 | | | | 35310529 | Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease |
| Polyphenols | 📋 | | | | 38539230 | Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome |
| Silibinin | 📋 | ✍ | | | 37473980 | Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model |
| Allicin | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| Baicalin | 📋 | ✍ | ⛔ | | 37719746 | An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer's disease rat model |
| Carvacrol | 📋 | ✍ | ⛔ | | 37047044 | Anti-Cholinesterase and Anti-α-Amylase Activities and Neuroprotective Effects of Carvacrol and p-Cymene and Their Effects on Hydrogen Peroxide Induced Stress in SH-SY5Y Cells |
| Citicoline | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 36958211 | Dihydromyricetin suppresses inflammatory injury in microglial cells to improve neurological behaviors of Alzheimer's disease mice via the TLR4/MD2 signal |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 36978877 | The Role of Fucoxanthin as a Potent Nrf2 Activator via Akt/GSK-3β/Fyn Axis against Amyloid-β Peptide-Induced Oxidative Damage |
| Garlic | 📋 | ✍ | ⛔ | | 36942042 | The Therapeutic Impact of Garlic (Allium Sativum) on Oxidative Stress Markers among Polycystic Ovary Syndrome Patients: A Randomized, Double-Blinded Clinical Trial |
| Lutein | 📋 | ✍ | ⛔ | | 37822286 | Lutein combined with EGCG improved retinitis pigmentosa against N-methyl- N nitrosourea-induced |
| Myricetin | 📋 | | ⛔ | | 38520750 | Myricetin ameliorates polycystic ovary syndrome in mice by brown adipose tissue activation |
| Rosemary | 📋 | ✍ | ⛔ | | 38258779 | Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies |
| Skullcap | 📋 | ✍ | ⛔ | | 38645989 | Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease |
| Taurine | 📋 | ✍ | ⛔ | | 38548872 | Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2 |
| Urolithins | 📋 | | | | 37335158 | Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity |
| Vitamin A | 📋 | ✍ | ⛔ | | 36728544 | Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation |
| Walnut | 📋 | | ⛔ | | 35565661 | Walnut Oil Reduces Aβ Levels and Increases Neurite Length in a Cellular Model of Early Alzheimer Disease |
| Wormwood | 📋 | ✍ | ⛔ | | 36999542 | Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation |
| Aged Garlic | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 37344230 | Association of Polyunsaturated Fatty Acids and Clinical Progression in Patients With ALS: Post Hoc Analysis of the EMPOWER Trial |
| Angelica | 📋 | ✍ | ⛔ | | 37639812 | The efficacy and mechanism of Angelica sinensis (Oliv.) Diels root aqueous extract based on RNA sequencing and 16S rDNA sequencing in alleviating polycystic ovary syndrome |
| Asiatic Acid | 📋 | | | | 32721993 | Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Centella asiatica |
| Astragalus Root | 📋 | ✍ | ⛔ | | 37824046 | Astragalus polysaccharide alleviates polycystic ovary syndrome by reducing insulin resistance and oxidative stress and increasing the diversity of gut microbiota |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 38143280 | Amelioration of Amyloid-β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3β/Wnt/β-Catenin Signaling |
| Capsaicin | 📋 | ✍ | ⛔ | | 37373321 | A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease |
| Catalpol | 📋 | | | | 37336148 | Catalpol rescues cognitive deficits by attenuating amyloid β plaques and neuroinflammation |
| Flaxseed | 📋 | ✍ | ⛔ | | 38063410 | The efficacy of Linum usitatissimum seeds to inhibit estrogen receptor as a natural therapy for PCOS: An in silico and in vitro analysis |
| Ganoderic Acid | 📋 | | | | 37287673 | Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA |
| Ginger | 📋 | ✍ | ⛔ | | 38671840 | Exploring the Antioxidative Effects of Ginger and Cinnamon: A Comprehensive Review of Evidence and Molecular Mechanisms Involved in Polycystic Ovary Syndrome (PCOS) and Other Oxidative Stress-Related Disorders |
| Hawthorn | 📋 | ✍ | ⛔ | | 36447359 | Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 37007297 | A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds ( Nigella sativa) in the Management of Polycystic Ovarian Syndrome (PCOS) |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Paeoniflorin | 📋 | | | | 38027768 | Network pharmacology and in vivo studies reveal the neuroprotective effects of paeoniflorin on Alzheimer's disease |
| Schisandrins | 📋 | | | | 36747236 | Combined with UPLC-Triple-TOF/MS-based plasma lipidomics and molecular pharmacology reveals the mechanisms of schisandrin against Alzheimer's disease |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 38599178 | Ganoderma lucidum and Hypericum perforatum exhibit anti-inflammatory, antioxidant and anti-androgen effect in rat model of experimental polycystic ovarian syndrome |
| Thymol | 📋 | ✍ | ⛔ | | 36808768 | Thymol in Trachyspermum ammi seed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine-induced Alzheimer's disease mouse model |
| Turmeric | 📋 | ✍ | ⛔ | | 36553450 | Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis-A Randomized, Double-Blinded, Placebo-Controlled Study |
| Vitamins | 📋 | | | | 38397800 | A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation |
| Bee Propolis | 📋 | ✍ | ⛔ | | 38583392 | Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 36982248 | β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38461353 | Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles |
| Betaine | 📋 | ✍ | ⛔ | | 37811321 | Making the case for prophylactic use of betaine to promote brain health in young (15-24 year old) athletes at risk for concussion |
| Blueberry | 📋 | ✍ | ⛔ | | 37647279 | Blueberry extracts antagonize Aβ25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 37864768 | Implication of Caffeic Acid for the Prevention and Treatment of Alzheimer's Disease: Understanding the Binding with Human Transferrin Using In Silico and In Vitro Approaches |
| Carotenoids | 📋 | ✍ | ⛔ | | 36480951 | Natural Carotenoids as Neuroprotective Agents for Alzheimer's Disease: An Evidence-Based Comprehensive Review |
| Chamomile | 📋 | ✍ | ⛔ | | 37465426 | Examining the Effect of Chamomile on Clinical Symptoms and Hormonal Parameters Among Patients With Polycystic Ovarian Syndrome |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38046466 | Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimer's disease model mice (APP/PS1) via the SIRT1/ /PGC-1α/PPARγ signaling pathway |
| Chokeberry | 📋 | ✍ | ⛔ | | 35739998 | Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome |
| Coptis Chinensis | 📋 | | ⛔ | | 38306514 | A network pharmacology method explores the molecular mechanism of Coptis chinensis for the treatment of Alzheimer's disease |
| Cordycepin | 📋 | | | | 37735930 | Cordycepin, a bioactive compound from Cordyceps spp., moderates Alzheimer's disease-associated pathology via anti-oxidative stress and autophagy activation |
| Dihydroquercetin | 📋 | | | | 38465425 | Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: Possible involvement of toll-like receptor 4 |
| Emodin | 📋 | | ⛔ | | 38405501 | Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer's Dementia: A Systematic Review |
| Fenugreek | 📋 | ✍ | ⛔ | | 37231762 | Pharmacological attributes of Fenugreek with special reference to Alzheimer's disease |
| Folate | 📋 | ✍ | ⛔ | | 37707697 | Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways |
| Frankincense | 📋 | ✍ | ⛔ | | 34542667 | Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer's disease |
| Fucoidan | 📋 | ✍ | ⛔ | | 36876791 | Fucoidans inhibited tau interaction and cellular uptake |
| Gingerol | 📋 | ✍ | | | 38397589 | Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets |
| Green Tea | 📋 | ✍ | ⛔ | | 36766162 | Computer-Aided Screening and Revealing Action Mechanism of Green Tea Polyphenols Intervention in Alzheimer's Disease |
| Hesperetin | 📋 | | | | 38517352 | Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids |
| Honokiol | 📋 | | | | 36873166 | Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis |
| Icaritin | 📋 | | | | 37990437 | Icaritin greatly attenuates β-amyloid-induced toxicity in vivo |
| Ligustilide | 📋 | | | | 33111362 | Ligustilide alleviates neurotoxicity in SH-SY5Y cells induced by Aβ25-35 via regulating endoplasmic reticulum stress and autophagy |
| Lotus | 📋 | | ⛔ | | 36757040 | Procyanidins extracted from the lotus seedpod ameliorate cognitive impairment through CREB-BDNF pathway mediated LTP in APP/PS1 transgenic mice |
| Magnolol | 📋 | | | | 36889111 | Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway |
| Morin | 📋 | | | | 38423257 | Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats |
| Mulberry | 📋 | | ⛔ | | 38612872 | Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays |
| Peony | 📋 | | ⛔ | | 35149132 | Paeonia lactiflora extract improves the muscle function of mdx mice, an animal model of Duchenne muscular dystrophy, via downregulating the high mobility group box 1 protein |
| Pine Bark | 📋 | ✍ | ⛔ | | 31958081 | Pine Bark Polyphenolic Extract Attenuates Amyloid-β and Tau Misfolding in a Model System of Alzheimer's Disease Neuropathology |
| Progesterone | 📋 | ✍ | ⛔ | | 35337126 | Topical Ocular Administration of Progesterone Decreases Photoreceptor Cell Death in Retinal Degeneration Slow (rds) Mice |
| Red Sage | 📋 | ✍ | ⛔ | | 37741257 | Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa |
| Sage | 📋 | ✍ | ⛔ | | 35137748 | Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model |
| Salvianolic Acid | 📋 | | | | 37913602 | Salvianolic acid B exerts protective effects against Aβ-induced neuroinflammation through the inhibition of NLRP3 inflammasome activation and switching of M1/M2 polarization |
| Spirulina | 📋 | ✍ | ⛔ | | 36861852 | The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double-blind, controlled trial |
| Telmisartan | 📋 | | ⛔ | | 37355897 | Telmisartan Alleviates Alzheimer's Disease-Related Neuropathologies and Cognitive Impairments |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 33602600 | Tribulus terrestris and female reproductive system health: A comprehensive review |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 38368515 | The Effects of Thiamine Supplementation on General Health and Infertility Treatment Outcomes in Women with Polycystic Ovary Syndrome: A Triple-Blinded Randomized Placebo-Controlled Clinical Trial |
| Aloe Vera | 📋 | ✍ | ⛔ | | 35928465 | Effect of Aloe vera ( Barbadensis Mill) on Letrozole Induced Polycystic Ovarian Syndrome in Swiss Albino Mice |
| Andrographis | 📋 | ✍ | ⛔ | | 38057817 | Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway |
| Asafoetida | 📋 | ✍ | ⛔ | | 37655000 | "Ferula assa-foetida L" or "Foeniculum vulgare"? Which one is more effective in the management of polycystic ovarian syndrome? A randomized, placebo controlled, triple-blinded |
| Asiaticoside | 📋 | | | | 37569347 | Asiaticoside Mitigates Alzheimer's Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function |
| Aspirin | 📋 | | ⛔ | | 36923554 | Efficacy of Low-Dose Aspirin in Colorectal Cancer Risk Prevention is Dependent on ADH1B and ALDH2 Genotype in Japanese Familial Adenomatous Polyposis Patients |
| Bilobalide | 📋 | | | | 34671017 | Bilobalide inhibits inflammation and promotes the expression of Aβ degrading enzymes in astrocytes to rescue neuronal deficiency in AD models |
| Black Pepper | 📋 | ✍ | ⛔ | | 34235220 | The Effect of a Traditional Preparation Containing Piper nigrum L. and Bunium persicum (Boiss.) B.Fedtsch. on Immobility Stress-Induced Memory Loss in Mice |
| Butyrate | 📋 | | ⛔ | | 37996797 | Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS |
| CAPE | 📋 | | | | 34529223 | Role of inflammation and oxidative stress in tissue damage associated with cystic fibrosis: CAPE as a future therapeutic strategy |
| Catechins | 📋 | | | | 35631180 | Catechins as a Potential Dietary Supplementation in Prevention of Comorbidities Linked with Down Syndrome |
| Chrysin | 📋 | ✍ | ⛔ | | 34151613 | Antisickling effect of chrysin is associated with modulation of oxygenated and deoxygenated haemglobin via alteration of functional chemistry and metabolic pathways of human sickle erythrocytes |
| Clove | 📋 | | ⛔ | | 37851769 | Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat |
| Cocoa | 📋 | ✍ | ⛔ | | 36083481 | Protective efficacy of dark chocolate in letrozole-induced ovary toxicity model rats: hormonal, biochemical, and histopathological investigation |
| Creatine | 📋 | ✍ | ⛔ | | 19476553 | Combination Therapy With Coenzyme Q10 and Creatine Produces Additive Neuroprotective Effects in Models of Parkinson's and Huntington's Diseases |
| Crocetin | 📋 | | | | 33404280 | Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway |
| Diosmetin | 📋 | | | | 37087594 | [Diosmetin regulates intestinal immune balance by inhibiting PI3K/AKT signaling to relieve 2, 4, 6-trinitrobenzene sulfonic acid-induced Crohn's disease-like colitis in mice] |
| Echinacoside | 📋 | | | | 35665898 | Echinacoside Improves Cognitive Impairment by Inhibiting Aβ Deposition Through the PI3K/AKT/Nrf2/PPARγ Signaling Pathways in APP/PS1 Mice |
| Eugenol | 📋 | | | | 37348246 | Eugenol relieves the pathological manifestations of Alzheimer's disease in 5×FAD mice |
| Formononetin | 📋 | | | | 35304289 | Formononetin attenuates Aβ25-35-induced adhesion molecules in HBMECs via Nrf2 activation |
| Galangal | 📋 | ✍ | ⛔ | | 36306920 | Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 34116484 | Increased pro-inflammatory cytokines in ovary and effect of γ-linolenic acid on adipose tissue inflammation in a polycystic ovary syndrome model |
| Geniposide | 📋 | | | | 34454545 | The emerging possibility of the use of geniposide in the treatment of cerebral diseases: a review |
| Ginger extract | 📋 | ✍ | ⛔ | | 33224329 | The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial |
| Haritaki | 📋 | ✍ | ⛔ | | 35696798 | Autophagy activation by Terminalia chebula Retz. reduce Aβ generation by shifting APP processing toward non-amyloidogenic pathway in APPswe transgenic SH-SY5Y cells |
| Hydroxytyrosol | 📋 | | | | 37834398 | The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease |
| L-Theanine | 📋 | ✍ | ⛔ | | 36185487 | Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea-land combination to retard brain aging |
| Lemon Balm | 📋 | ✍ | ⛔ | | 34201872 | The Stimulating Effect of Rosmarinic Acid and Extracts from Rosemary and Lemon Balm on Collagen Type I Biosynthesis in Osteogenesis Imperfecta Type I Skin Fibroblasts |
| Linalool | 📋 | | ⛔ | | 38723901 | Linalool acts as a chemical chaperone by inhibiting amyloid-β aggregation |
| Mangiferin | 📋 | | ⛔ | | 37521470 | Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington's disease-like symptoms in rats: possible antioxidant and anti-inflammatory mechanisms |
| Nicotinamide | 📋 | ✍ | ⛔ | | 38044436 | Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy |
| Olive Polyphenols | 📋 | | | | 29772299 | Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.) |
| Persimmon | 📋 | | ⛔ | | 34205542 | Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 27829013 | Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice |
| Prebiotics | 📋 | ✍ | ⛔ | | 38495755 | Gut microbiota and its metabolites in Alzheimer's disease: from pathogenesis to treatment |
| Quercitrin | 📋 | | | | 37321077 | Quercitrin alleviates lipid metabolism disorder in polycystic ovary syndrome-insulin resistance by upregulating PM20D1 in the PI3K/Akt pathway |
| Spermidine | 📋 | | | | 38401586 | Synergistic effect of spermidine and ciprofloxacin against Alzheimer's disease in male rat via ferroptosis modulation |
| Stigmasterol | 📋 | | | | 38461353 | Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 38623153 | Effect of vitamin D3 and a stinging nettle extract on the gastric tissue of rats administered with trinitrobenzene sulfonic acid |
| Tanshinone | 📋 | | | | 38659601 | Tanshinone IIA improves Alzheimer's disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis |
| Tea | 📋 | | | | 38714417 | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| Tetrahydrocurcumin | 📋 | ✍ | | | 34679727 | Tetrahydrocurcumin Has Similar Anti-Amyloid Properties as Curcumin: In Vitro Comparative Structure-Activity Studies |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 37508330 | The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot-Marie-Tooth Disease with the Compromised Status of Vitamin-Dependent Processes |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 37508330 | The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot-Marie-Tooth Disease with the Compromised Status of Vitamin-Dependent Processes |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 35034906 | Zeaxanthin Attenuates the Vicious Circle Between Endoplasmic Reticulum Stress and Tau Phosphorylation: Involvement of GSK-3β Activation |
| Almond | 📋 | | ⛔ | | 32368208 | Effect of Prunus dulcis and Salvia hispenica in the management of polycystic ovary syndrome in Wistar rats |
| Arctigenin | 📋 | | | | 38104254 | Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism |
| Artemisinin | 📋 | | | | 36902054 | Loss of Extrasynaptic Inhibitory Glycine Receptors in the Hippocampus of an AD Mouse Model Is Restored by Treatment with Artesunate |
| Asparagus | 📋 | | ⛔ | | 34492320 | Qisheng Wan formula ameliorates cognitive impairment of Alzheimer's disease rat via inflammation inhibition and intestinal microbiota regulation |
| Basil | 📋 | ✍ | ⛔ | | 35000160 | Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery |
| Bee Venom | 📋 | ✍ | ⛔ | | 37317907 | Memory Enhancing and Neurogenesis Activity of Honey Bee Venom in the Symptoms of Amnesia: Using Rats with Amnesia-like Alzheimer's Disease as a Model |
| Bilberry | 📋 | ✍ | ⛔ | | 32003387 | Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia |
| Cardamom | 📋 | ✍ | ⛔ | | 36522620 | Effect of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with polycystic ovary syndrome: a double blind randomized controlled trial |
| Carnosic Acid | 📋 | | | | 36224322 | Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells |
| Cinnamaldehyde | 📋 | | | | 31910792 | Sub-chronic oral cinnamaldehyde treatment prevents scopolamine-induced memory retrieval deficit and hippocampal Akt and MAPK dysregulation in male mice |
| Coconut | 📋 | | ⛔ | | 29188860 | A Keto-Mediet Approach with Coconut Substitution and Exercise May Delay the Onset of Alzheimer's Disease among Middle-Aged |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 36028179 | Conjugated linoleic acid downregulates Alzheimer's hallmarks in aluminum mouse model through an Nrf2-mediated adaptive response and increases brain glucose transporter levels |
| Copper | 📋 | ✍ | ⛔ | | 36195639 | Brain copper may protect from cognitive decline and Alzheimer's disease pathology: a community-based study |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 32785956 | Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity |
| Cyanidin | 📋 | ✍ | | | 38705400 | Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling |
| Date | 📋 | | ⛔ | | 36654869 | Effects of Phoenix dactylifera against Streptozotocin-Aluminium Chloride Induced Alzheimer's Rats and Their In Silico Study |
| Fiber | 📋 | ✍ | ⛔ | | 38142919 | Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 36433633 | The effects of flaxseed or its oil supplementations on polycystic ovary syndrome: A systematic review of clinical trials |
| Galangin | 📋 | | | | 36834819 | Galangin Rescues Alzheimer's Amyloid-β Induced Mitophagy and Brain Organoid Growth Impairment |
| Gardenia | 📋 | | ⛔ | | 38000495 | Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome |
| Grape | 📋 | | ⛔ | | 36342065 | Grape juice reduces the effects of amyloid β aggregation phenotype and extends the longevity in Caenorhabditis elegans |
| Holy Basil | 📋 | ✍ | ⛔ | | 35900690 | Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels |
| Honey | 📋 | ✍ | ⛔ | | 37570596 | Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids |
| Hyperoside | 📋 | | | | 36821955 | Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice |
| Irisin | 📋 | | | | 38658376 | Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 34568497 | A Review on Therapeutic Effects of Labisia pumila on Female Reproductive Diseases |
| Kaempferol | 📋 | ✍ | ⛔ | | 35929364 | Kaempferol as a potential neuroprotector in Alzheimer's disease |
| Kudzu Root | 📋 | ✍ | ⛔ | | 33433542 | In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 33052945 | Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 35877305 | Lion's Mane ( Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model |
| Liquiritigenin | 📋 | | | | 33965487 | Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease |
| Liquiritin | 📋 | | | | 35733703 | Protective effects of liquiritin on polycystic ovary syndrome through modulating ovarian granulosa cell proliferation and apoptosis via miR-206/PI3K/AKT pathway |
| Lychee | 📋 | | ⛔ | | 31917277 | Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway |
| Mushrooms | 📋 | | ⛔ | | 37569241 | Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer's Disease |
| NAD | 📋 | | | | 34440204 | NAD + Precursors and Antioxidants for the Treatment of Amyotrophic Lateral Sclerosis |
| Neferine | 📋 | | | | 37891552 | Liensinine and neferine exert neuroprotective effects via the autophagy pathway in transgenic Caenorhabditis elegans |
| Nootkatone | 📋 | | | | 32565596 | Network Pharmacology-Based Study on the Mechanism of Schisandra chinensis for Treating Alzheimer's Disease |
| Nutmeg | 📋 | ✍ | ⛔ | | 35662922 | Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35201555 | A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats |
| Patchouli | 📋 | ✍ | ⛔ | | 36717922 | Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway |
| Pelargonidin | 📋 | | | | 35694918 | Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study |
| Punicalagin | 📋 | ✍ | ⛔ | | 37092799 | Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 36986277 | Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 35411448 | Bio-enhancement of Soy Isoflavones (Genistein & Daidzein) Using Bacillus coagulans in Letrozole Induced Polycystic Ovarian Syndrome by Regulating Endocrine Hormones in Rats |
| Spikenard | 📋 | ✍ | ⛔ | | 35864434 | Jatamansinol from Nardostachys jatamansi Ameliorates Tau-Induced Neurotoxicity in Drosophila Alzheimer's Disease Model |
| Strawberry | 📋 | ✍ | ⛔ | | 33547659 | Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer's disease |
| Tangeretin | 📋 | | | | 35084179 | Tangeretin Inhibits BACE1 Activity and Attenuates Cognitive Impairments in AD Model Mice |
| Tannic Acid | 📋 | ✍ | ⛔ | | 37712018 | A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease |
| Trehalose | 📋 | | ⛔ | | 37776526 | Trehalose consumption ameliorates pathogenesis in an inducible mouse model of the Fragile X-associated tremor/ataxia syndrome |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 32416962 | Cerebral Deficiency of Vitamin B5 (D-Pantothenic Acid; Pantothenate) as a Potentially-Reversible Cause of Neurodegeneration and Dementia in Sporadic Alzheimer's Disease |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 34199021 | Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37477796 | Vitamin K2 protects against aluminium chloride-mediated neurodegeneration |
| Whey Protein | 📋 | ✍ | ⛔ | | 37414601 | Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway |
| Withaferin A | 📋 | | | | 34204308 | Role of Withaferin A and Its Derivatives in the Management of Alzheimer's Disease: Recent Trends and Future Perspectives |
| Withanolides | 📋 | | | | 32748763 | Integrated system pharmacology and in silico analysis elucidate neuropharmacological actions of Withania somnifera in the treatment of Alzheimer's disease |
| Wogonin | 📋 | ✍ | ⛔ | | 33147823 | Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation |
| Acacetin | 📋 | | | | 36382256 | Acacetin improves cognitive function of APP/PS1 Alzheimer's disease model mice via the NLRP3 inflammasome signaling pathway |
| Aloe-Emodin | 📋 | | | | 37191091 | Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 34323669 | Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD |
| Atractylodes | 📋 | ✍ | ⛔ | | 36164880 | [Mechanism of Atractylodes macrocephala against Alzheimer's disease via regulating lysophagy based on LKB1-AMPK-TFEB pathway] |
| Balloon Flower | 📋 | ✍ | ⛔ | | 34943071 | Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways |
| Berries | 📋 | | | | 29401686 | Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 36890624 | β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites |
| Biochanin A | 📋 | | | | 37230376 | Biochanin-A attenuates DHEA-induced polycystic ovary syndrome via upregulation of GDF9 and BMP15 signaling in vivo |
| Bitter Melon | 📋 | ✍ | ⛔ | | 36902074 | The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease |
| Bitter Orange | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Blackcurrant | 📋 | ✍ | ⛔ | | 35790009 | Anthocyanin-rich blackcurrant extract improves long-term memory impairment and emotional abnormality in senescence-accelerated mice |
| Boric Acid | 📋 | ✍ | ⛔ | | 37220543 | Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer's Disease |
| Bromelain | 📋 | ✍ | ⛔ | | 36462588 | Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway |
| Calcium | 📋 | ✍ | ⛔ | | 35088227 | Effect of calcium and vitamin D supplementation on the clinical, hormonal, and metabolic profile in non-obese women with polycystic ovary syndrome |
| Calycosin | 📋 | | | | 36195188 | Calycosin ameliorates advanced glycation end product-induced neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease |
| Carnosol | 📋 | | | | 36786429 | Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1-mediated Nrf2/HO-1 activation |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 38053824 | Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system |
| Cinnamic Acid | 📋 | | | | 33662757 | A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease |
| Colostrum | 📋 | ✍ | ⛔ | | 36364868 | Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn's Disease; A Feasibility Study |
| Cordyceps | 📋 | ✍ | ⛔ | | 34936310 | Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycota), Attenuates Aβ1-42-Induced Amyloidogenesis and Inflammatory Response by Suppressing Amyloid Precursor Protein Progression and p38 MAPK/JNK Activation |
| Coumaric acid | 📋 | | | | 37414223 | p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model |
| Cryptotanshinone | 📋 | | | | 37879506 | Mechanism of cryptotanshinone to improve endocrine and metabolic functions in the endometrium of PCOS rats |
| Dioscin | 📋 | | | | 35691153 | Dioscin alleviates Alzheimer's disease through regulating RAGE/NOX4 mediated oxidative stress and inflammation |
| Diosgenin | 📋 | | | | 37085711 | Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer's disease model mice |
| Diosmin | 📋 | ✍ | ⛔ | | 34522212 | Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin |
| Eleuthero | 📋 | ✍ | ⛔ | | 38545117 | Acanthopanax senticosus improves cognitive impairment in Alzheimer's disease by promoting the phosphorylation of the MAPK signaling pathway |
| Emu Oil | 📋 | ✍ | ⛔ | | 32903038 | Orally administered emu oil attenuates disease in a mouse model of Crohn's-like colitis |
| Eucommia | 📋 | ✍ | ⛔ | | 35754707 | Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer's Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 32522946 | Fish Oil and Primrose Oil Suppress the Progression of Alzheimer's Like Disease Induced by Aluminum in Rats |
| Fermented Foods | 📋 | | ⛔ | | 37967591 | Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 29668503 | Tetrahydroxystilbene glycoside antagonizes β-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression |
| GABA | 📋 | ✍ | ⛔ | | 36734072 | The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression |
| Genipin | 📋 | | | | 37865990 | Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease |
| Geraniol | 📋 | | | | 37054939 | Geraniol improves passive avoidance memory and hippocampal synaptic plasticity deficits in a rat model of Alzheimer's disease |
| Giloy | 📋 | ✍ | ⛔ | | 37901891 | Therapeutic Effect of Tinospora cordifolia (Willd) Extracts on Letrozole-Induced Polycystic Ovarian Syndrome and its Complications in Murine Model |
| Glutathione | 📋 | ✍ | ⛔ | | 35310529 | Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease |
| Guggulsterone | 📋 | | | | 38170440 | Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples |
| Hazelnut | 📋 | | ⛔ | | 29208493 | Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents |
| HMB | 📋 | ✍ | ⛔ | | 37626825 | Does β-Hydroxy-β-Methylbutyrate Have Any Potential to Support the Treatment of Duchenne Muscular Dystrophy in Humans and Animals? |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 36158563 | Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease |
| Isorhamnetin | 📋 | | | | 36842967 | Isorhamnetin inhibits inflammatory response to alleviate DHEA-induced polycystic ovary syndrome in rats |
| Lavender | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Licochalcones | 📋 | | | | 37762479 | Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 34111468 | Protective effect of alpha-linoleic acid on Aβ-induced oxidative stress, neuroinflammation, and memory impairment by alteration of α7 nAChR and NMDAR gene expression in the hippocampus of rats |
| Mangosteen | 📋 | ✍ | ⛔ | | 35415207 | Effects of water-soluble mangosteen extract on cognitive function and neuropsychiatric symptoms in patients with mild to moderate Alzheimer's disease (WECAN-AD): A randomized controlled trial |
| Nattokinase | 📋 | ✍ | ⛔ | | 37263404 | Nattokinase prevents β-amyloid peptide (Aβ1-42) induced neuropsychiatric complications, neuroinflammation and BDNF signalling disruption in mice |
| Onion | 📋 | ✍ | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Oolong Tea | 📋 | | ⛔ | | 35629970 | Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice |
| Paeonol | 📋 | | | | 34997723 | Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice |
| Plum | 📋 | | ⛔ | | 30577585 | Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential Oils as Antioxidant and of Cholinesterases Inhibitors |
| PUFA | 📋 | | | | 33774033 | Can polyunsaturated fatty acids regulate Polycystic Ovary Syndrome via TGF-β signalling? |
| Raspberry | 📋 | ✍ | ⛔ | | 30397021 | Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington's Disease |
| Rehmannia | 📋 | ✍ | ⛔ | | 35784741 | Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer's Disease |
| Rose | 📋 | | | | 37078068 | Effect of Rosa damascena Extract on Rat Model Alzheimer's Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study |
| Roselle | 📋 | ✍ | ⛔ | | 32480228 | Hibiscus Sabdariffa L.: A Potent Natural Neuroprotective Agent for the Prevention of Streptozotocin-Induced Alzheimer's Disease in Mice |
| Royal Jelly | 📋 | ✍ | ⛔ | | 36809522 | Royal jelly improves learning and memory deficits in an amyloid β-induced model of Alzheimer's disease in male rats: Involvement of oxidative stress |
| Safranal | 📋 | | | | 37910529 | Effect of safranal or candesartan on 3-nitropropionicacid-induced biochemical, behavioral and histological alterations in a rat model of Huntington's disease |
| Senolytics | 📋 | | | | 37874084 | Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics |
| Serrapeptase | 📋 | ✍ | ⛔ | | 35694981 | The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach |
| Sesame Oil | 📋 | | ⛔ | | 36810739 | Ameliorative effect of sesame oil on experimentally induced polycystic ovary syndrome: A cross-link between XBP-1/PPAR-1, regulatory proteins for lipogenesis/steroids |
| Soy | 📋 | ✍ | ⛔ | | 32417364 | Soy flavonoids prevent cognitive deficits induced by intra-gastrointestinal administration of beta-amyloid |
| Soy Protein | 📋 | ✍ | ⛔ | | 38257177 | Effects of Soy Protein Isolate on Fragile X Phenotypes in Mice |
| Spearmint | 📋 | | ⛔ | | 32197626 | A combination of spearmint and flaxseed extract improved endocrine and histomorphology of ovary in experimental PCOS |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 31772594 | Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections |
| Spices | 📋 | | | | 34279199 | Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease |
| UDCA | 📋 | ✍ | ⛔ | | 22301109 | Ursodeoxycholate modulates bile flow and bile salt pool independently from the cystic fibrosis transmembrane regulator (Cftr) in mice |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 36618920 | Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer's disease |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 36543778 | Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation |
| 5-HTP | 📋 | ✍ | ⛔ | | 14527871 | The serotonin precursor 5-hydroxytryptophan delays neuromuscular disease in murine familial amyotrophic lateral sclerosis |
| Acai Berry | 📋 | ✍ | ⛔ | | 35956841 | A Preliminary Assessment of the Nutraceutical Potential of Acai Berry ( Euterpe sp.) as a Potential Natural Treatment for Alzheimer's Disease |
| Alpha GPC | 📋 | ✍ | ⛔ | | 38595916 | Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease |
| Amino Acids | 📋 | | | | 37509672 | What Nutraceuticals Can Do for Duchenne Muscular Dystrophy: Lessons Learned from Amino Acid Supplementation in Mouse Models |
| Anethole | 📋 | | | | 36029056 | The Protective Effects of Trans-Anethole against Polycystic Ovary Syndrome Induced Histopathological and Metabolic Changes in Rat |
| Anthocyanidins | 📋 | | | | 31847371 | Association of Strawberries and Anthocyanidin Intake with Alzheimer's Dementia Risk |
| Apple | 📋 | | ⛔ | | 26298312 | Effects of an Antioxidant Beverage on Biomarkers of Oxidative Stress in Alzheimer's Patients |
| Astragalin | 📋 | | | | 36681681 | Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice |
| Bamboo | 📋 | ✍ | ⛔ | | 38334213 | The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model |
| Barberry | 📋 | ✍ | ⛔ | | 36186093 | Neuroprotective Effect of Root Extracts of Berberis Vulgaris (Barberry) on Oxidative Stress on SH-SY5Y Cells |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 29356981 | Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus |
| Bee Pollen | 📋 | ✍ | ⛔ | | 33555077 | Synergic effect of bee pollen and metformin on proliferation and apoptosis of granulosa cells: Rat model of polycystic ovary syndrome |
| Beets | 📋 | ✍ | ⛔ | | 33054666 | Beetroot supplemented diet exhibit anti-amnesic effect via modulation of cholinesterases, purinergic enzymes, monoamine oxidase and attenuation of redox imbalance in the brain of scopolamine treated male rats |
| Bergamot | 📋 | ✍ | ⛔ | | 26853104 | Citrus bergamia Juice Extract Attenuates β-Amyloid-Induced Pro-Inflammatory Activation of THP-1 Cells Through MAPK and AP-1 Pathways |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 27444300 | The effect of taurine and β-alanine supplementation on taurine transporter protein and fatigue resistance in skeletal muscle from mdx mice |
| Black Cohosh | 📋 | ✍ | ⛔ | | 33926485 | Modulation of steroidogenesis by Actaea racemosa and vitamin C combination, in letrozole induced polycystic ovarian syndrome rat model: promising activity without the risk of hepatic adverse effect |
| Black Ginger | 📋 | ✍ | ⛔ | | 36904098 | Kaempferia parviflora Extracts Protect Neural Stem Cells from Amyloid Peptide-Mediated Inflammation in Co-Culture Model with Microglia |
| Black Tea | 📋 | ✍ | ⛔ | | 35320401 | The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis |
| Blackberry | 📋 | | ⛔ | | 38430352 | Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling |
| Cannabidiol Oil | 📋 | ✍ | ⛔ | | 29786144 | Self-initiated use of topical cannabidiol oil for epidermolysis bullosa |
| Cardamonin | 📋 | | | | 36672126 | The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer's Disease |
| Cashew | 📋 | | ⛔ | | 34576912 | Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer's Disease |
| Cat's Claw | 📋 | ✍ | ⛔ | | 17294693 | Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40) |
| Cedarwood Essential Oil | 📋 | ✍ | ⛔ | | 32037737 | Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 38229887 | Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease |
| Chebulinic Acid | 📋 | | | | 37453379 | Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses |
| Chicoric Acid | 📋 | | | | 38542381 | Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models |
| Chlorella | 📋 | ✍ | ⛔ | | 37144207 | Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease |
| Clove Essential Oil | 📋 | | ⛔ | | 37119836 | Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease |
| Coriander | 📋 | | ⛔ | | 27776428 | Coriandrum sativum Suppresses Aβ42-Induced ROS Increases, Glial Cell Proliferation, and ERK Activation |
| Corn Silk | 📋 | ✍ | ⛔ | | 37563784 | Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation |
| Cornus | 📋 | | | | 34689137 | Loganin substantially ameliorates molecular deficits, pathologies and cognitive impairment in a mouse model of Alzheimer's disease |
| Cranberry | 📋 | ✍ | ⛔ | | 27473960 | Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease |
| Dandelion | 📋 | ✍ | ⛔ | | 35053874 | Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo |
| Deodar Cedar | 📋 | | | | 36690306 | Cedrus deodara (Roxb. ex D.Don) G.Don bark fraction ameliorates metabolic, endocrine and ovarian dynamics in rats experiencing polycystic ovarian syndrome |
| DHEA | 📋 | ✍ | ⛔ | | 12562454 | Patients With Refractory Crohn's Disease or Ulcerative Colitis Respond to Dehydroepiandrosterone: A Pilot Study |
| Dihydroartemisinin | 📋 | | | | 32210783 | Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer's Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance |
| Docosapentaenoic Acid | 📋 | ✍ | | | 33178186 | The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models |
| Elderberry | 📋 | ✍ | ⛔ | | 33745925 | Elderberry diet ameliorates motor function and prevents oxidative stress-induced cell death in rat models of Huntington disease |
| Essential Fatty Acids | 📋 | ✍ | | | 36364928 | Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex |
| Essential Oils | 📋 | | ⛔ | | 30360002 | Essential Oils as Treatment Strategy for Alzheimer's Disease: Current and Future Perspectives |
| Eucalyptus | 📋 | ✍ | ⛔ | | 35298858 | Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial |
| Fig | 📋 | | ⛔ | | 24938828 | Consumption of fig fruits grown in Oman can improve memory, anxiety, and learning skills in a transgenic mice model of Alzheimer's disease |
| Fish Collagen | 📋 | ✍ | ⛔ | | 20150601 | Effect of Exclusion Diet With Nutraceutical Therapy in Juvenile Crohn's Disease |
| Forskolin | 📋 | ✍ | ⛔ | | 33037790 | Forskolin rapidly enhances neuron-like morphological change of directly induced-neuronal cells from neurofibromatosis type 1 patients |
| Fruits | 📋 | | | | 38347678 | Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study |
| Fufang Danshen | 📋 | | | | 29770796 | Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease |
| Ginkgetin | 📋 | | | | 29214278 | Ginkgetin Ameliorates Neuropathological Changes in APP/PS1 Transgenical Mice Model |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 37115805 | Glycyrrhizin ameliorates impaired glucose metabolism and ovarian dysfunction in a polycystic ovary syndrome mouse model |
| Grape Seed Oil | 📋 | | ⛔ | | 32665902 | Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases |
| Horse Chestnut | 📋 | ✍ | ⛔ | | 32158393 | Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells |
| Hypericin | 📋 | | | | 37183545 | Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning |
| Indian Gooseberry | 📋 | | ⛔ | | 36046175 | Revealing the Acetylcholinesterase Inhibitory Potential of Phyllanthus amarus and Its Phytoconstituents: In Vitro and in Silico Approach |
| Inulin | 📋 | ✍ | ⛔ | | 35057459 | Yogurt Enriched with Inulin Ameliorated Reproductive Functions and Regulated Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice |
| Iron | 📋 | ✍ | ⛔ | | 15482288 | Vitamin and trace metal levels in recessive dystrophic epidermolysis bullosa |
| Isoflavones | 📋 | ✍ | ⛔ | | 38590945 | Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review) |
| Isoliquiritigenin | 📋 | | | | 25782036 | Extracts of Glycyrrhiza uralensis and isoliquiritigenin counteract amyloid-β toxicity in Caenorhabditis elegans |
| Jujube | 📋 | | ⛔ | | 35922734 | An aqueous macerate of Ziziphus jujuba reduces long-term spatial memory impairment in D-galactose treated rats: role of anti-inflammatory pathways |
| Krill Oil | 📋 | ✍ | ⛔ | | 36185487 | Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea-land combination to retard brain aging |
| L-Carnosine | 📋 | ✍ | ⛔ | | 35091983 | Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin |
| L-Citrulline | 📋 | ✍ | ⛔ | | 33940559 | Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease |
| L-Histidine | 📋 | ✍ | ⛔ | | 36164730 | Histidine supplementation can escalate or rescue HARS deficiency in a Charcot Marie Tooth Disease model |
| L-Leucine | 📋 | ✍ | ⛔ | | 38382647 | Vcp overexpression and leucine supplementation extend lifespan and ameliorate neuromuscular junction phenotypes of a SOD1G93A-ALS mouse model |
| L-Lysine | 📋 | ✍ | ⛔ | | 21127688 | Could Lysine Supplementation Prevent Alzheimer's Dementia? A Novel Hypothesis |
| L-Methionine | 📋 | ✍ | ⛔ | | 33457340 | The Effects of Zinc Methionine on Reproductive and Thyroid Hormones in Rats with Polycystic Ovarian Syndrome |
| Lauric Acid | 📋 | ✍ | | | 27430387 | Lauric Acid Stimulates Ketone Body Production in the KT-5 Astrocyte Cell Line |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 33052945 | Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation |
| Lettuce | 📋 | | ⛔ | | 35101010 | In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa |
| Lupeol | 📋 | | | | 37447385 | A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer's Disease |
| Madecassoside | 📋 | | | | 32721993 | Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Centella asiatica |
| Malvidin | 📋 | | | | 35874261 | Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property |
| Mango Leaf | 📋 | | ⛔ | | 27537110 | Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model |
| Marigold | 📋 | ✍ | ⛔ | | 35845946 | The Effect of Hydroalcoholic Calendula Officinalis Extract on Androgen-Induced Polycystic Ovary Syndrome Model in Female Rat |
| Marjoram | 📋 | | ⛔ | | 32877649 | The ameliorative effects of marjoram in dehydroepiandrosterone induced polycystic ovary syndrome in rats |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 28102336 | Differential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS |
| Myrtle | 📋 | ✍ | ⛔ | | 30553998 | Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors |
| Neem Oil | 📋 | ✍ | ⛔ | | 30993302 | Treatment of Peristomal granulomatosis with a Neem and Red Hypericum Oil application: Case studies |
| Neohesperidin | 📋 | | | | 33581209 | Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics |
| Nitrate | 📋 | ✍ | ⛔ | | 20089363 | Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease |
| Oats | 📋 | | ⛔ | | 34684684 | Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice |
| Okra | 📋 | | ⛔ | | 37358589 | Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function |
| Oleic Acid | 📋 | | ⛔ | | 36965537 | Oleic acid prevents erythrocyte death by preserving haemoglobin and erythrocyte membrane proteins |
| Orange | 📋 | | ⛔ | | 36678510 | Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 33052945 | Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation |
| Pantethine | 📋 | ✍ | ⛔ | | 37194410 | Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species |
| Parthenolide | 📋 | | | | 37992573 | Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway |
| PEA | 📋 | ✍ | ⛔ | | 34658885 | Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunctions in a Mouse Model of Alzheimer's Disease |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 36986277 | Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition |
| Perilla | 📋 | ✍ | | | 29092397 | Alpha-Linolenic Acid From Perilla Frutescens Var. Japonica Oil Protects Aβ-Induced Cognitive Impairment Through Regulation of APP Processing and Aβ Degradation |
| Phosphatidylcholine | 📋 | ✍ | ⛔ | | 32797252 | Choline in cystic fibrosis: relations to pancreas insufficiency, enterohepatic cycle, PEMT and intestinal microbiota |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 33163896 | Effects of a Nutritional Formulation Containing Caprylic and Capric Acid, Phosphatidylserine, and Docosahexaenoic Acid in Streptozotocin-Lesioned Rats |
| Phytoestrogens | 📋 | | ⛔ | | 34527172 | The Beneficial Role of Natural Endocrine Disruptors: Phytoestrogens in Alzheimer's Disease |
| Pine Needle Essential Oil | 📋 | ✍ | ⛔ | | 33655878 | Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus |
| Pine Nut | 📋 | | ⛔ | | 37821052 | Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease |
| Pomegranate Seed extract | 📋 | | ⛔ | | 35257560 | The effect of pomegranate seed oil on human health, especially epidemiology of polycystic ovary syndrome; a systematic review |
| Postbiotics | 📋 | | | | 37934614 | Gut microbiome-targeted therapies for Alzheimer's disease |
| PQQ | 📋 | ✍ | ⛔ | | 38454653 | Deep Learning-Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease |
| Pregnenolone | 📋 | ✍ | ⛔ | | 31794725 | Pregnenolone and pregnenolone-methyl-ether rescue neuronal defects caused by dysfunctional CLIP170 in a neuronal model of CDKL5 Deficiency Disorder |
| Procyanidins | 📋 | | ⛔ | | 31917277 | Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway |
| Protein | 📋 | ✍ | ⛔ | | 38674911 | Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60 |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 24804206 | Pu-erh tea extract induces the degradation of FET family proteins involved in the pathogenesis of amyotrophic lateral sclerosis |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 37324929 | Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females |
| Rapeseed Oil | 📋 | ✍ | | | 33514384 | The effects of canola and olive oils consumption compared to sunflower oil, on lipid profile and hepatic steatosis in women with polycystic ovarian syndrome: a randomized controlled trial |
| Retinoic Acid | 📋 | | | | 35315776 | Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration |
| Rosavin | 📋 | | ⛔ | | 37758932 | Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model |
| Rose Essential Oil | 📋 | | | | 38688895 | A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats |
| Rosehip | 📋 | ✍ | ⛔ | | 27563424 | Neuroprotective Effects of Herbal Extract (Rosa canina, Tanacetum vulgare and Urtica dioica) on Rat Model of Sporadic Alzheimer's Disease |
| Safflower | 📋 | ✍ | ⛔ | | 35053874 | Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo |
| SAMe | 📋 | ✍ | ⛔ | | 32597804 | S-Adenosylmethionine Alleviates Amyloid-β-Induced Neural Injury by Enhancing Trans-Sulfuration Pathway Activity in Astrocytes |
| Scutellarein | 📋 | | | | 37239029 | A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease |
| Scutellarin | 📋 | | | | 35964195 | Scutellarin Modulates the Microbiota-Gut-Brain Axis and Improves Cognitive Impairment in APP/PS1 Mice |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 37132070 | Polysaccharides from sea buckthorn (Hippophae rhamnoides L.) berries ameliorates cognitive dysfunction in AD mice induced by a combination of D-gal and AlCl3 by suppressing oxidative stress and inflammation reaction |
| Seafood | 📋 | | | | 36354985 | Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect |
| Seaweeds | 📋 | | ⛔ | | 36662216 | Application of Marine Natural Products against Alzheimer's Disease: Past, Present and Future |
| Sesame | 📋 | ✍ | ⛔ | | 37324929 | Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females |
| Sesamin | 📋 | ✍ | | | 36847969 | Effects of sesamin on Aβ1-42-induced oxidative stress and LTP impairment in a rat model of Alzheimer's disease |
| Sesamol | 📋 | | | | 34669408 | Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 Mice: The Mediating Role of the Gut-Brain Axis |
| Shilajit | 📋 | ✍ | ⛔ | | 37513872 | Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer's Disease |
| Sorghum | 📋 | | ⛔ | | 34690742 | Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article |
| St. Johns Wort Oil | 📋 | | ⛔ | | 30993302 | Treatment of Peristomal granulomatosis with a Neem and Red Hypericum Oil application: Case studies |
| Star Fuit | 📋 | | ⛔ | | 30196278 | Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease |
| Stevia | 📋 | ✍ | ⛔ | | 35444350 | Histomorphological Changes in a Rat Model of Polycystic Ovary Syndrome and the Contribution of Stevia Leaf Extract in Modulating the Ovarian Fibrosis, VEGF, and TGF-β Immunoexpressions: Comparison with Metformin |
| Sunflower | 📋 | | ⛔ | | 37324929 | Effectiveness of combined seeds (pumpkin, sunflower, sesame, flaxseed): As adjacent therapy to treat polycystic ovary syndrome in females |
| Sweet Potato | 📋 | | ⛔ | | 35720655 | Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction |
| Syringic Acid | 📋 | | | | 34599991 | Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease |
| Tamarind | 📋 | | ⛔ | | 35481086 | The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches |
| Theobromine | 📋 | ✍ | ⛔ | | 27792010 | Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model |
| Thyme Essential Oil | 📋 | | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Trans-Resveratrol | 📋 | | | | 34402024 | Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial |
| Valerian Root | 📋 | ✍ | ⛔ | | 26976216 | Sesquiterpenes and a monoterpenoid with acetylcholinesterase (AchE) inhibitory activity from Valeriana officinalis var. latiofolia in vitro and in vivo |
| Vitamin B Complex | 📋 | | ⛔ | | 15790610 | Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 31873717 | Riboflavin Supplementation in Patients with Crohn's Disease [the RISE-UP study] |
| Vitamin K1 | 📋 | ✍ | ⛔ | | 18511355 | Efficacy of High Dose Phylloquinone in Correcting Vitamin K Deficiency in Cystic Fibrosis |
| Vitex | 📋 | ✍ | ⛔ | | 34046325 | Effect of Vitex agnus-castus ethanolic extract on hypothalamic KISS-1 gene expression in a rat model of polycystic ovary syndrome |
| Vitexin | 📋 | | | | 32926499 | Vitexin prevents Aβ proteotoxicity in transgenic Caenorhabditis elegans model of Alzheimer's disease by modulating unfolded protein response |
| Watercress | 📋 | ✍ | ⛔ | | 36351033 | Nasturtium officinale L. and metformin alleviate the estradiol -induced polycystic ovary syndrome with synergistic effects through modulation of Bax/Bcl-2/p53/caspase-3 signaling pathway and anti-inflammatory and anti-oxidative effects |
| White Mushrooms | 📋 | | ⛔ | | 36291298 | White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease |
| Wine | 📋 | | ⛔ | | 26092624 | Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer's Disease |
| Wood Ear Mushrooms | 📋 | | ⛔ | | 35467804 | Human Hemoglobin S Erythrocyte-Stabilizing and Antisickling Potential of Extract of Wood Ear Mushroom, Auricularia auricula (Agaricomycetes) |
| Xylitol | 📋 | ✍ | ⛔ | | 36154609 | Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice |
| Yogurt | 📋 | | ⛔ | | 35057459 | Yogurt Enriched with Inulin Ameliorated Reproductive Functions and Regulated Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice |
